ageLOC Y-Span Clinical Studies ข้อมูลอ้างอิงในการศึกษาทางคลินิก
ข้อมูลอ้างอิงในการศึกษาทางคลินิกที่เกี่ยวกับผลิตภัณฑ์ ageLOC Y-Span
Reference materials on the different clinical studies of the ageLoc Y-Span product.

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Studies to Support Ingredients Present in All Global Formulas

1. Garg, A., S. Garg, L. J. Zaneveld and A. K. Singla (2001). “Chemistry and pharmacology of the Citrus bio­flavonoid hesperidin.” Phytother Res 15(8): 655-669. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/11746857

2. Schmidt, S., F. Stahl, K. O. Mutz, T. Scheper, A. Hahn and J. P. Schuchardt (2012). “Different gene expression profiles in normo- and dyslipidemic men after fish oil supplementation: results from a randomized controlled trial.” Lipids Health Dis 11: 105. Free full-length study at: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3484010/pdf/1476-511X-11-105.pdf

3. Bouwens, M., O. van de Rest, N. Dellschaft, M. G. Bromhaar, L. C. de Groot, J. M. Geleijnse, M. Muller and L. A. Afman (2009). “Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells.” Am J Clin Nutr 90(2): 415-424. Free full-length study at: //ajcn.nutrition.org/content/90/2/415.full.pdf+html

4. Morrow, D. M., P. E. Fitzsimmons, M. Chopra and H. McGlynn (2001). “Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation.” Mutat Res 480-481: 269-276. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/11506819

5. Devaraj, S., S. Mathur, A. Basu, H. H. Aung, V. T. Vasu, S. Meyers and I. Jialal (2008). “A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress.” J Am Coll Nutr 27(2): 267-273. Free full-length study at: //www.ncbi.nlm.nih.gov/pmc/articles/PMC2677959/pdf/nihms95342.pdf

Studies to Support Ingredients Present in All Global Formulas Except Greater China
1. Yoon, W. J., N. H. Lee and C. G. Hyun (2010). “Limo­nene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages.” J Oleo Sci 59(8): 415-421. Free full-length study at: //www.jstage.jst.go.jp/article/jos/59/8/59_8_415/_pdf

2. Lee, D.M. et al (2009). “Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.” J Neurol Neurosurg Psychiatry 80(7): 722-729. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/19460797

3. Zhu, H., D. Guo, K. Li, J. Pedersen-White, I. S. Stall­mann-Jorgensen, Y. Huang, S. Parikh, K. Liu and Y. Dong (2012). “Increased telomerase activity and vitamin D supplementation in overweight African Americans.” Int J Obes (Lond) 36(6): 805-809. Free full-length study at: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3826782/pdf/nihms526393.pdf

4. Pengelly, A., J. Snow, S. Y. Mills, A. Scholey, K. Wesnes and L. R. Butler (2012). “Short-term study on the effects of rosemary on cognitive function in an elderly population.” J Med Food 15(1): 10-17. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/21877951

Studies to Support Ingredients Present in Many of the Global Formulas

1. Villalba, I. Tunez, F. Perez-Jimenez and J. Lopez- Miranda (2013). “Postprandial antioxidant gene expres­sion is modified by Mediterranean diet supplemented with coenzyme Q(10) in elderly men and women.” Age (Dordr) 35(1): 159-170. Free full-length study at: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3543746/pdf/11357_2011_Article_9331.pdf

2. Schrauwen, E. C. Mariman and E. E. Blaak (2013). “The effects of 30 days resveratrol supplementation on adi­pose tissue morphology and gene expression patterns in obese men.” Int J Obes (Lond). Abstract at: //www.ncbi.nlm.nih.gov/pubmed/23958793

3. Li, J., M. K. Kang, J. K. Kim, J. L. Kim, S. W. Kang, S. S. Lim and Y. H. Kang (2012). “Purple corn anthocyanins retard diabetes-associated glomerulosclerosis in mesan­gial cells and db/db mice.” Eur J Nutr 51(8): 961-973. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/22102159

4. Tsuda, T., F. Horio, K. Uchida, H. Aoki and T. Osawa (2003). “Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.” J Nutr 133(7): 2125-2130. Free full-length study at: //jn.nutrition.org/content/133/7/2125.full.pdf+html

5. Djordjevic, B., I. Baralic, J. Kotur-Stevuljevic, A. Stefa­novic, J. Ivanisevic, N. Radivojevic, M. Andjelkovic and N. Dikic (2012). “Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players.” J Sports Med Phys Fitness 52(4): 382-392. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/22828460

6. K. Lee and Y. M. Kim (2003). “Astaxanthin inhibits nitric oxide production and inflammatory gene expres­sion by suppressing I(kappa)B kinase-dependent NF-kappaB activation.” Mol Cells 16(1): 97-105. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/14503852

7. Stoll, S., H. Hartmann, S. A. Cohen and W. E. Muller (1993). “The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relation­ship to NMDA receptor deficits.” Pharmacol Biochem Behav 46(4): 799-805. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/8309958

8. Liu, J. (2008). “The effects and mechanisms of mito­chondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.” Neurochem Res 33(1): 194-203. Abstract at: //www.ncbi.nlm.nih.gov/pubmed/17605107

Below are the following studies provided by our Provo team involving different aspects of YSpan: bone, cartilage, and joint health.

ageLOC-Y-Span-Clinical-Studies

Bone Health:

1. Citrus Bioflavonoids
a. Habauzit V, Sacco SM, Gil-Izquierdo A, Trzeciakiewicz A, Morand C, Barron D, Pinaud S, Offord E, Horcajada MN. Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism. Bone. 2011 Nov;49(5):1108-16. [abstract]

b. Trzeciakiewicz A, Habauzit V, Mercier S, Lebecque P, Davicco MJ, Coxam V, Demigne C, Horcajada MN. Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway. J Nutr Biochem. 2010 May;21(5):424-31.[abstract]
c. Sun X, Fengbo LI, Xinlong MA, Jianxiong MA, Zhao B, Zhang Y, Yanjun LI, Jianwei LV, Meng X. The Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats. Sci Rep. 2015 Aug 11;5:13009.[free full-length study]
d. Wang D, Ma W, Wang F, Dong J, Wang D, Sun B, Wang B. Stimulation of Wnt/β-Catenin Signaling to Improve Bone Development by Naringin via Interacting with AMPK and Akt. Cell Physiol Biochem. 2015;36(4):1563-76. [free full-length study]
e. Fan J, Li J, Fan Q. Naringin promotes differentiation of bone marrow stem cells into osteoblasts by upregulating the expression levels of microRNA‑20a and downregulating the expression levels of PPARγ. Mol Med Rep. 2015 Sep;12(3):4759-65.[abstract]

2. Omega-3 Fatty Acids

a. Dong H, Hutchins-Wiese H, Kleppinger A, Annis K, Liva E, Lammi-Keefe C, Durham H, Feinn R, Kenny AM. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. Int J Vitam Nutr Res. 2014;84(3-4):124-32.[abstract]
b. Matsushita H, Barrios JA, Shea JE, Miller SC. Dietary fish oil results in a greater bone mass and bone formation indices in aged ovariectomized rats. J Bone Miner Metab. 2008;26(3):241-7.[abstract]
c. Bhattacharya A, Rahman M, Sun D, Fernandes G. Effect of fish oil on bone mineral density in aging C57BL/6 female mice. J Nutr Biochem. 2007 Jun;18(6):372-9.[abstract]

3. Lycopene
a. Sołtysiak P, Folwarczna J. [Effects of lycopene on the skeletal system]. Postepy Hig Med Dosw (Online). 2015 Feb 21;69:243-51. Review.[abstract]

b. Sacco SM, Horcajada MN, Offord E. Phytonutrients for bone health during ageing. Br J Clin Pharmacol. 2013 Mar;75(3):697-707.[free full-length paper, see page 698 for Lycopene discussion]
c. Mackinnon ES, Rao AV, Rao LG. Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women. J Nutr Health Aging. 2011 Feb;15(2):133-8.[abstract]

4. Quercetin

a. Inoue J, Choi JM, Yoshidomi T, Yashiro T, Sato R. Quercetin enhances VDR activity, leading to stimulation of its target gene expression in Caco-2 cells. J Nutr Sci Vitaminol (Tokyo). 2010;56(5):326-30.[free full-length study]

b. Liang W, Luo Z, Ge S, Li M, Du J, Yang M, Yan M, Ye Z, Luo Z. Oral administration of quercetin inhibits bone loss in rat model of diabetic osteopenia. Eur J Pharmacol. 2011 Nov 16;670(1):317-24.[abstract]
5. Vitamin D

a. Bhan I. Vitamin d binding protein and bone health. Int J Endocrinol. 2014;2014:561214. doi: 10.1155/2014/561214. Epub 2014 Jun 1. Review.[free full-length article]
b. Ebeling PR. Vitamin D and bone health: Epidemiologic studies. Bonekey Rep. 2014 Mar 5;3:511. doi: 10.1038/bonekey.2014.6. eCollection 2014. Review. [free full-length article]

6. CoQ10

a. Kömürcü E, Oktay M, Kaymaz B, Hatay Gölge U, Göksel F, Nusran G. Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats. Acta Orthop Traumatol Turc. 2014;48(2):217-22.[free full length article]
b. Moon HJ, Ko WK, Jung MS, Kim JH, Lee WJ, Park KS, Heo JK, Bang JB, Kwon IK. Coenzyme q10 regulates osteoclast and osteoblast differentiation. J Food Sci. 2013 May;78(5):H785-891.[abstract]

7. Resveratrol

a. Feng J, Liu S, Ma S, Zhao J, Zhang W, Qi W, Cao P, Wang Z, Lei W. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2014 Dec;46(12):1024-33. [abstract]
b. Ornstrup MJ, Harsløf T, Kjær TN, Langdahl BL, Pedersen SB. Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. J Clin Endocrinol Metab. 2014 Dec;99(12):4720-9.[abstract]

8. Alpha-Lipoic Acid

a. Roberts JL, Moreau R. Emerging role of alpha-lipoic acid in the prevention and treatment of bone loss.Nutr Rev. 2015 Feb;73(2):116-25.[abstract]
b. Fu C, Xu D, Wang CY, Jin Y, Liu Q, Meng Q, Liu KX, Sun HJ, Liu MZ. Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats. J Cell Physiol. 2015 Sep;230(9):2184-201.[abstract]

Cartilage/Joint Health:
Wang Y, Wluka AE, Hodge AM, English DR, Giles GG, O’Sullivan R, Cicuttini FM. “Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis.” Osteoarthritis Cartilage. 2008 May;16(5):579-83. //www.ncbi.nlm.nih.gov/pubmed/17937997

Sung MS, Lee EG, Jeon HS, Chae HJ, Park SJ, Lee YC, Yoo WH. “Quercetin inhibits IL-1β-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.” Inflammation. 2012 Aug;35(4):1585-94. //www.ncbi.nlm.nih.gov/pubmed/22592909
Manna SK, Mukhopadhyay A, Aggarwal BB. “Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation.” J Immunol. 2000 Jun 15;164(12):6509-19. //www.ncbi.nlm.nih.gov/pubmed/10843709/
Curtis CL, Rees SG, Cramp J, Flannery CR, Hughes CE, Little CB, Williams R, Wilson C, Dent CM, Harwood JL, Caterson B. “Effects of n-3 fatty acids on cartilage metabolism.” Proc Nutr Soc. 2002 Aug;61(3):381-9. Retraction in: Curtis CL, Rees SG, Cramp J, Flannery CR, Hughes CE, Little CB, Williams R, Wilson C, Dent CM, Harwood JL, Caterson B. Proc Nutr Soc. 2006 Nov;65(4):434. //www.ncbi.nlm.nih.gov/pubmed/12230798

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